Diabetology & Metabolic Syndrome (Oct 2024)

The role of incretins in gestational diabetes: a case-control study on the impact of obesity

  • Engin Yurtcu,
  • Betul Keyif,
  • Gamze Yilmaz,
  • Selcuk Erkilinc,
  • Hatice Akkaya,
  • A. Seval Ozgu-Erdinc

DOI
https://doi.org/10.1186/s13098-024-01483-w
Journal volume & issue
Vol. 16, no. 1
pp. 1 – 10

Abstract

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Abstract Background This study aimed to evaluate the role of serum Glucagon-Like Peptide-1 (GLP-1), Glucagon-Like Peptide-2 (GLP-2), and Glucose-Dependent Insulinotropic Polypeptide (GIP) levels in relation to obesity and gestational diabetes mellitus (GDM) in pregnancy. Methods A case-control study was conducted, including 96 pregnant women with singleton pregnancies who underwent the Oral Glucose Tolerance Test (OGTT) for GDM diagnosis during the 24th–28th weeks of gestation. Blood samples were collected for measuring GLP-1, GLP-2, GIP, and fasting glucose. Statistical analyses included receiver operating characteristic (ROC) curves and correlation analysis. Results Among the 96 women, no significant difference in age was observed between the groups, but Body Mass Index (BMI) was significantly higher in GDM-O (Gestational Diabetes Mellitus-Obese) and non-GDM-O groups (p 0.05). Conclusions Impaired secretion of GLP-1, GLP-2, and GIP likely contributes to the pathogenesis of GDM. GLP-1 may serve as a potential biomarker for diagnosing GDM.

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