Emphasise the effect of Covid-19 patients on antihypertensive drugs in a tertiary care hospital – a cross sectional study

Abstract

Objectives: The SARS-CoV-2-associated pneumonia (COVID-19) infection has spread quickly throughout China and the rest of the world since December 2019. SARS-CoV-2 has been demonstrated to interact with the RAAS and endothelin systems to both initiate "de novo" onset hypertension and exacerbate pre-existing instances. This study described the clinical symptoms, therapeutic outcomes of COVID in 19 patients with hypertension. Methods: Data collection forms were used to gather information on demographics, clinical, laboratory, radiological parameters and treatment outcomes from the medical records provided by 195 Covid-19-infected patients admitted to the KMCH institute of health sciences and research in Coimbatore. The 2019-CoV RNA real-time reverse transcription polymerase chain reaction (RT-PCR) assay was developed to test patients with Covid-19. The patients were split into normotensives (137) and hypertensives (58) with covid infection. Results and Discussion: CORADS score was used to classify the severity of Pneumonia. None of the hypertensives had a severity score of 3. 15.35% had a severity score of 2 and 82.8% had a severity score of 1. When the severity score was compared with normotensives, there was no significant difference among both the groups. None of the patient needed intensive care. The means of various clinical (blood and physical) parameters were compared between hypertensives and non-hypertensives. The mean age of hypertensives was 58.7 compared to 42.44 among normotensives (P<0.001). No significant difference among both the groups with respect to SPO2, Plasma Glucose (random), sodium, potassium, chloride, systolic blood pressure and hospital stay. There was a significant difference in diastolic blood pressure. (p<0.05). Conclusion: Results of this study showed difference in the treatment outcome in hypertensives compared to normotensives is not significant. p values that lack statistical significance may not accurately represent the state of the entire population.

Keywords

• covid-19
• hypertension
• clinical profile
• treatment outcome