FEATURES OF SECONDARY IMMUNE DEFICIENCY IN PATIENTS WITH ACUTE DESTRUCTIVE PANCREATITIS

Abstract

Abstract. Immunological characteristics of phagocytic activity and cellular immunity are presented for 112 patients with acute destructive pancreatitis with suppurative complications (group I), versus non-septic cases. We evaluated lymphocyte subpopulation profiles, phagocytic activity of leukocytes, serum levels of interferon-γ and circulating immune complexes. A mixed-type secondary immune deficiency was shown to develop in pancreatic necrosis. Distinct signs typical to immune deficiency, as well as lack of cellular immune potential were evident as soon as by day 3 of the disease.

Keywords

• pancreatic necrosis
• secondary immune deficiency
• phagocytic capacity