THE EFFECT OF LITHIUM ON ACUTE TOXICITY OF CHLORPROMAZINE IN MICE

Abstract

The effects of chronic administration of lithium, on acute toxicity of chlorpromazine (CPZ) in male albino mice was studied and the LDSO values were determined from dose-probit curves. Tfie results showed that in lithium pretrealed animals (anmials consumed drinking water containing 600mg/L lithium chloride for 10 days) the LD50 value (the dose corresponding to probit 5) of CPZ increased significantly from 27.99±0.29 to 45.5±0.47 mg/kg. It seems that concurrent administration of lithium with CPZ decreases the acute toxicity of CPZ in mice. Several interactions between phenothiazines and lithium has been described. It is concluded that concurrent use of lithium anil CPZ, decreases the acute toxicity of CPZ in mice and such interaction may reduce CPZ response. the lithium-induced reduction of CPZ lethality may be due to pharmacokinetics and pharmucrttlvnamics inleractions.

Keywords

• chlorpromazine
• lethality, mice