IL-17-producing γδ T cells enhance bone regeneration

Takehito Ono; Kazuo Okamoto; Tomoki Nakashima; Takeshi Nitta; Shohei Hori; Yoichiro Iwakura; Hiroshi Takayanagi

doi:10.1038/ncomms10928

Nature Communications (Mar 2016)

IL-17-producing γδ T cells enhance bone regeneration

Takehito Ono,
Kazuo Okamoto,
Tomoki Nakashima,
Takeshi Nitta,
Shohei Hori,
Yoichiro Iwakura,
Hiroshi Takayanagi

Affiliations

Takehito Ono: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Kazuo Okamoto: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Tomoki Nakashima: Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Takeshi Nitta: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Shohei Hori: Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Science
Yoichiro Iwakura: Research Institute for Biological Sciences, Tokyo University of Science
Hiroshi Takayanagi: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo

DOI: https://doi.org/10.1038/ncomms10928
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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