Clinicopathological Profile of Primary Gastric Lymphoma - A Retrospective and Observational Study

Abstract

Introduction: Primary gastric lymphoma (PGL) accounts for <15% of all the gastric malignances and <2% of all the lymphomas. Although they can involve any part of gastric tract, however, stomach is predominantly involved. Clinically, it is difficult to diagnose gastric lymphoma as it does not present with specific symptoms. Materials and Methods: It was a retrospective study carried out from July 16 to July 20. Patient's data were obtained from clinical record sheets. Histopathological examination was performed followed by panel of immunohistochemistry with leukocyte common antigen, CD 3, CD138, CD10, CD5, CD79a, CD20, Bcl-2, Bcl-6, Cyclin D1, and Ki-67. Further subtyping of gastric NHL was done using immunohistochemistry. Results: A total of 30 patients of PGL were included in the study. There were 23 males and 7 females, with M:F of 3.1:1. The mean age of presentation was 53 years. Abdominal pain and dyspepsia were common symptoms at presentation. Gastric antrum was the common site of involvement. Diffuse large B-cell lymphoma germinal center type was the most common histological variant seen in the present study. Helicobacter pylori was seen in 9 cases (30%) cases. Majority of patients were diagnosed in Stage II and III. Conclusion: PGL clinically is difficult to diagnose because of its nonspecific symptoms. Endoscopic examination should be done in such patients. All these suspicious patients should undergo biopsy examination of the lesion.

Keywords

• diffuse large b-cell lymphoma
• maltoma
• primary gastric lymphoma