Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier

Patrick H. Kee, MD, PhD; Melanie R. Moody, BSc; Shao-Ling Huang, PhD; Hyunggun Kim, PhD; Xing Yin, MD, PhD; Tao Peng, MD; Susan T. Laing, MD; Melvin E. Klegerman, PhD; Mohammad H. Rahbar, PhD; Deborah Vela, MD; Curtis Genstler, MD, PhD; Kevin J. Haworth, PhD; Christy K. Holland, PhD; David D. McPherson, MD

JACC: Basic to Translational Science (Jan 2020)

Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier

Patrick H. Kee, MD, PhD,
Melanie R. Moody, BSc,
Shao-Ling Huang, PhD,
Hyunggun Kim, PhD,
Xing Yin, MD, PhD,
Tao Peng, MD,
Susan T. Laing, MD,
Melvin E. Klegerman, PhD,
Mohammad H. Rahbar, PhD,
Deborah Vela, MD,
Curtis Genstler, MD, PhD,
Kevin J. Haworth, PhD,
Christy K. Holland, PhD,
David D. McPherson, MD

Affiliations

Patrick H. Kee, MD, PhD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas; Address for correspondence: Dr. Patrick H. Kee, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, 3SCRB 6.4607, Houston, Texas 77054-6011.
Melanie R. Moody, BSc: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
Shao-Ling Huang, PhD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
Hyunggun Kim, PhD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas; Department of Bio-Mechatronic Engineering, Sungkyunkwan University, Suwon, Republic of Korea
Xing Yin, MD, PhD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
Tao Peng, MD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
Susan T. Laing, MD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
Melvin E. Klegerman, PhD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas
Mohammad H. Rahbar, PhD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas; Center for Clinical and Translational Sciences, The University of Texas Health Science Center at Houston, Houston, Texas
Deborah Vela, MD: Department of Pathology, Texas Heart Institute, Houston, Texas
Curtis Genstler, MD, PhD: EKOS Corporation, Bothell, Washington
Kevin J. Haworth, PhD: Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio
Christy K. Holland, PhD: Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio
David D. McPherson, MD: Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas

Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Summary: Late in-stent restenosis remains a significant problem. Bare-metal stents were implanted into peripheral arteries in miniature swine, followed by direct intra-arterial infusion of nitric oxide–loaded echogenic liposomes (ELIPs) and anti–intercellular adhesion molecule-1 conjugated ELIPs loaded with pioglitazone exposed to an endovascular catheter with an ultrasonic core. Ultrasound-facilitated delivery of ELIP formulations into stented peripheral arteries attenuated neointimal growth. Local atheroma-targeted, ultrasound-triggered delivery of nitric oxide and pioglitazone, an anti-inflammatory peroxisome proliferator–activated receptor-γ agonist, into stented arteries has the potential to stabilize stent-induced neointimal growth and obviate the need for long-term antiplatelet therapy. Key Words: atherosclerosis, in-stent restenosis, nitric oxide, pioglitazone, ultrasound contrast agent

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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