Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

Ryuhei Nagata; Masahiro Fujihashi; Takaaki Sato; Haruyuki Atomi; Kunio Miki

doi:10.1038/s41467-018-04201-z

Nature Communications (May 2018)

Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

Ryuhei Nagata,
Masahiro Fujihashi,
Takaaki Sato,
Haruyuki Atomi,
Kunio Miki

Affiliations

Ryuhei Nagata: Department of Chemistry, Graduate School of Science, Kyoto University
Masahiro Fujihashi: Department of Chemistry, Graduate School of Science, Kyoto University
Takaaki Sato: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura
Haruyuki Atomi: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura
Kunio Miki: Department of Chemistry, Graduate School of Science, Kyoto University

DOI: https://doi.org/10.1038/s41467-018-04201-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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