Nature Communications (Mar 2022)
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
- Diego Sáenz de Urturi,
- Xabier Buqué,
- Begoña Porteiro,
- Cintia Folgueira,
- Alfonso Mora,
- Teresa C. Delgado,
- Endika Prieto-Fernández,
- Paula Olaizola,
- Beatriz Gómez-Santos,
- Maider Apodaka-Biguri,
- Francisco González-Romero,
- Ane Nieva-Zuluaga,
- Mikel Ruiz de Gauna,
- Naroa Goikoetxea-Usandizaga,
- Juan Luis García-Rodríguez,
- Virginia Gutierrez de Juan,
- Igor Aurrekoetxea,
- Valle Montalvo-Romeral,
- Eva M. Novoa,
- Idoia Martín-Guerrero,
- Marta Varela-Rey,
- Sanjay Bhanot,
- Richard Lee,
- Jesus M. Banales,
- Wing-Kin Syn,
- Guadalupe Sabio,
- María L. Martínez-Chantar,
- Rubén Nogueiras,
- Patricia Aspichueta
Affiliations
- Diego Sáenz de Urturi
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Xabier Buqué
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Begoña Porteiro
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Cintia Folgueira
- Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Alfonso Mora
- Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Teresa C. Delgado
- Liver Disease Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance)
- Endika Prieto-Fernández
- Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country UPV/EHU
- Paula Olaizola
- Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute—Donostia University Hospital, University of the Basque Country (UPV/EHU)
- Beatriz Gómez-Santos
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Maider Apodaka-Biguri
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Francisco González-Romero
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Ane Nieva-Zuluaga
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Mikel Ruiz de Gauna
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Naroa Goikoetxea-Usandizaga
- Liver Disease Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance)
- Juan Luis García-Rodríguez
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Virginia Gutierrez de Juan
- Liver Disease Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance)
- Igor Aurrekoetxea
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Valle Montalvo-Romeral
- Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Eva M. Novoa
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Idoia Martín-Guerrero
- Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country UPV/EHU
- Marta Varela-Rey
- Liver Disease Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance)
- Sanjay Bhanot
- IONIS Pharmaceuticals
- Richard Lee
- IONIS Pharmaceuticals
- Jesus M. Banales
- Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute—Donostia University Hospital, University of the Basque Country (UPV/EHU)
- Wing-Kin Syn
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- Guadalupe Sabio
- Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- María L. Martínez-Chantar
- Liver Disease Laboratory, CIC bioGUNE-BRTA (Basque Research & Technology Alliance)
- Rubén Nogueiras
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Patricia Aspichueta
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
- DOI
- https://doi.org/10.1038/s41467-022-28749-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.
