Crystal structure of E. coli apolipoprotein N-acyl transferase

Guangyuan Lu; Yingzhi Xu; Kai Zhang; Yong Xiong; He Li; Lei Cui; Xianping Wang; Jizhong Lou; Yujia Zhai; Fei Sun; Xuejun C. Zhang

doi:10.1038/ncomms15948

Nature Communications (Jul 2017)

Crystal structure of E. coli apolipoprotein N-acyl transferase

Guangyuan Lu,
Yingzhi Xu,
Kai Zhang,
Yong Xiong,
He Li,
Lei Cui,
Xianping Wang,
Jizhong Lou,
Yujia Zhai,
Fei Sun,
Xuejun C. Zhang

Affiliations

Guangyuan Lu: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Yingzhi Xu: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Kai Zhang: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Yong Xiong: Department of Molecular Biophysics and Biochemistry, Yale University
He Li: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Lei Cui: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Xianping Wang: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Jizhong Lou: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Yujia Zhai: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Fei Sun: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences
Xuejun C. Zhang: National Laboratory of Macromolecules, Institute of Biophysics, CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms15948
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Apolipoprotein N-acyl transferase (Lnt) catalyses the final step in the protein lipidation pathway of Gram-negative bacteria. Here, the authors present the crystal structure ofE. coliLnt, which consists of a transmembrane domain and a nitrilase domain localised at the periplasmic side of the membrane.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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