Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation

Kyung Cheul Shin; Injae Hwang; Sung Sik Choe; Jeu Park; Yul Ji; Jong In Kim; Gha Young Lee; Sung Hee Choi; Jianhong Ching; Jean-Paul Kovalik; Jae Bum Kim

doi:10.1038/s41467-017-01232-w

Nature Communications (Oct 2017)

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation

Kyung Cheul Shin,
Injae Hwang,
Sung Sik Choe,
Jeu Park,
Yul Ji,
Jong In Kim,
Gha Young Lee,
Sung Hee Choi,
Jianhong Ching,
Jean-Paul Kovalik,
Jae Bum Kim

Affiliations

Kyung Cheul Shin: Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University
Injae Hwang: Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University
Sung Sik Choe: Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University
Jeu Park: Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University
Yul Ji: Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University
Jong In Kim: Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University
Gha Young Lee: Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital
Sung Hee Choi: Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital
Jianhong Ching: Cardiovascular and Metabolic Disorders, Duke-NUS Medical School
Jean-Paul Kovalik: Cardiovascular and Metabolic Disorders, Duke-NUS Medical School
Jae Bum Kim: Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University

DOI: https://doi.org/10.1038/s41467-017-01232-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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VLDLR regulates cellular lipoprotein uptake and storage. Here, the authors show that VLDLR, expressed on adipose tissue macrophages, is upregulated in obesity and promotes adipose tissue inflammation by upregulating ceramide production and facilitating M1-like macrophage polarization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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