Associations between nocturnal bedtime and asthma among adults in the United States

Abstract

Abstract Background Sleep disorders have a significant impact on asthma. The aim of this study was to explore the association between nocturnal bedtime and asthma among adults in the United States. Methods This study was a cross-sectional analysis involving 11,475 participants from the National Health and Nutrition Examination Survey (NHANES) during the period of 2015–2018. Nocturnal bedtime was categorized into three distinct groups: 2100 h or earlier, between 2100 h and 2300 h, and 2300 h or later. The association between night bedtime and asthma was detected using multivariable logistic regression analyses. Additionally, subgroup analyses were conducted to assess the impact of subgroups. Results After adjustment for confounders, a positive association was revealed between later bedtime (after 2300 h) and the prevalence of asthma (OR = 1.20, 95%CI: 1.01–1.43). In the subgroup analysis, the following factors were associated with increased risk: 18–39 years (OR = 1.23, 95%CI: 1.02–1.48); female sex (OR = 1.30, 95%CI: 1.01–1.68); Hispanic patients (OR = 1.66, 95%CI: 1.17–2.37); heavy drinkers (OR = 1.52, 95%CI: 1.17–1.96); Body Mass Index (BMI) (< 25 kg/m2) (OR = 1.45, 95%CI: 1.13–1.87); vigorous physical activity (OR = 1.32, 95%CI: 1.05–1.65);Significant interactions were found between nocturnal bedtime and asthma based on age, sex, eosinophils (EOS) percent and depression (P Interaction < 0.05). Conclusion Our results confirmed a moderately increased risk of asthma attributed to later bedtime, especially in 18–39 years, women and patients of Hispanic ethnicity. Future studies should investigate the underlying mechanisms of this association and explore the clinical implications for asthma management.

Keywords

• Sleep disorders
• Circadian rhythm
• Asthma
• National health and nutrition examination survey (NHANES)
• A cross-sectional survey