Nature Communications (Dec 2020)

A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding

  • B. Sofia Beas,
  • Xinglong Gu,
  • Yan Leng,
  • Omar Koita,
  • Shakira Rodriguez-Gonzalez,
  • Morgan Kindel,
  • Bridget A. Matikainen-Ankney,
  • Rylan S. Larsen,
  • Alexxai V. Kravitz,
  • Mark A. Hoon,
  • Mario A. Penzo

DOI
https://doi.org/10.1038/s41467-020-19980-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Catecholaminergic neurons of the ventrolateral medulla are known to drive diverse glucose counterregulatory responses to hypoglycemia. Here, the authors show that projections from these neurons onto nucleus accumbens-targeting neurons of the midline thalamus selectively mediate hypoglycemic feeding.