Nature Communications (Jan 2019)

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

  • Alena V. Yermalovich,
  • Jihan K. Osborne,
  • Patricia Sousa,
  • Areum Han,
  • Melissa A. Kinney,
  • Michael J. Chen,
  • Daisy A. Robinton,
  • Helen Montie,
  • Dan S. Pearson,
  • Sean B. Wilson,
  • Alexander N. Combes,
  • Melissa H. Little,
  • George Q. Daley

DOI
https://doi.org/10.1038/s41467-018-08127-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regulating the duration of nephrogenesis.