The DNA methylome of cervical cells can predict the presence of ovarian cancer

James E. Barrett; Allison Jones; Iona Evans; Daniel Reisel; Chiara Herzog; Kantaraja Chindera; Mark Kristiansen; Olivia C. Leavy; Ranjit Manchanda; Line Bjørge; Michal Zikan; David Cibula; Martin Widschwendter

doi:10.1038/s41467-021-26615-y

Nature Communications (Feb 2022)

The DNA methylome of cervical cells can predict the presence of ovarian cancer

James E. Barrett,
Allison Jones,
Iona Evans,
Daniel Reisel,
Chiara Herzog,
Kantaraja Chindera,
Mark Kristiansen,
Olivia C. Leavy,
Ranjit Manchanda,
Line Bjørge,
Michal Zikan,
David Cibula,
Martin Widschwendter

Affiliations

James E. Barrett: European Translational Oncology Prevention and Screening (EUTOPS) Institute
Allison Jones: Department of Women’s Cancer, UCL EGA Institute for Women’s Health, University College London
Iona Evans: Department of Women’s Cancer, UCL EGA Institute for Women’s Health, University College London
Daniel Reisel: Department of Women’s Cancer, UCL EGA Institute for Women’s Health, University College London
Chiara Herzog: European Translational Oncology Prevention and Screening (EUTOPS) Institute
Kantaraja Chindera: Department of Women’s Cancer, UCL EGA Institute for Women’s Health, University College London
Mark Kristiansen: UCL Genomics, Zayed Centre for Research into Rare Disease in Children, University College London
Olivia C. Leavy: Department of Health Sciences, University of Leicester
Ranjit Manchanda: Department of Gynaecological Oncology, Barts Health NHS Trust, Royal London Hospital
Line Bjørge: Department of Obstetrics and Gynaecology, Haukeland University Hospital
Michal Zikan: Hospital Na Bulovce
David Cibula: Department of Obstetrics and Gynecology, General University Hospital in Prague, First Faculty of Medicine, Charles University
Martin Widschwendter: European Translational Oncology Prevention and Screening (EUTOPS) Institute

DOI: https://doi.org/10.1038/s41467-021-26615-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Most ovarian cancers originate from cells originally derived from Müllerian Duct cells. Here, the authors show that the methylation profile of Müllerian Duct cells isolated from cervical samples can predict whether a woman has cervical cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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