Nature Communications (Sep 2022)
Heterologous vector versus homologous mRNA COVID-19 booster vaccination in non-seroconverted immunosuppressed patients: a randomized controlled trial
- Daniel Mrak,
- Daniela Sieghart,
- Elisabeth Simader,
- Selma Tobudic,
- Helga Radner,
- Peter Mandl,
- Lisa Göschl,
- Maximilian Koblischke,
- Nikolaus Hommer,
- Angelika Wagner,
- Margareta Mayer,
- Lorenz Schubert,
- Lukas Hartl,
- Karin Kozbial,
- Philipp Hofer,
- Felix Kartnig,
- Thomas Hummel,
- Andreas Kerschbaumer,
- Thomas Deimel,
- Antonia Puchner,
- Venugopal Gudipati,
- Renate Thalhammer,
- Petra Munda,
- Keziban Uyanik-Ünal,
- Andreas Zuckermann,
- Gottfried Novacek,
- Thomas Reiberger,
- Erika Garner-Spitzer,
- Roman Reindl-Schwaighofer,
- Renate Kain,
- Stefan Winkler,
- Josef S. Smolen,
- Karin Stiasny,
- Gottfried F. Fischer,
- Thomas Perkmann,
- Helmuth Haslacher,
- Markus Zeitlinger,
- Ursula Wiedermann,
- Judith H. Aberle,
- Daniel Aletaha,
- Leonhard X. Heinz,
- Michael Bonelli
Affiliations
- Daniel Mrak
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Daniela Sieghart
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Elisabeth Simader
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Selma Tobudic
- Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna
- Helga Radner
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Peter Mandl
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Lisa Göschl
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Maximilian Koblischke
- Center for Virology, Medical University of Vienna
- Nikolaus Hommer
- Department of Clinical Pharmacology, Medical University of Vienna
- Angelika Wagner
- Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna
- Margareta Mayer
- Center for Virology, Medical University of Vienna
- Lorenz Schubert
- Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna
- Lukas Hartl
- Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna
- Karin Kozbial
- Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna
- Philipp Hofer
- Department of Pathology, Medical University of Vienna
- Felix Kartnig
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Thomas Hummel
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Andreas Kerschbaumer
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Thomas Deimel
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Antonia Puchner
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Venugopal Gudipati
- Institute of Hygiene and Applied Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna
- Renate Thalhammer
- Department of Laboratory Medicine, Medical University of Vienna
- Petra Munda
- Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna
- Keziban Uyanik-Ünal
- Department of Cardiac Surgery, Medical University of Vienna
- Andreas Zuckermann
- Department of Cardiac Surgery, Medical University of Vienna
- Gottfried Novacek
- Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna
- Thomas Reiberger
- Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna
- Erika Garner-Spitzer
- Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna
- Roman Reindl-Schwaighofer
- Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna
- Renate Kain
- Department of Pathology, Medical University of Vienna
- Stefan Winkler
- Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna
- Josef S. Smolen
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Karin Stiasny
- Center for Virology, Medical University of Vienna
- Gottfried F. Fischer
- Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna
- Thomas Perkmann
- Department of Laboratory Medicine, Medical University of Vienna
- Helmuth Haslacher
- Department of Laboratory Medicine, Medical University of Vienna
- Markus Zeitlinger
- Department of Clinical Pharmacology, Medical University of Vienna
- Ursula Wiedermann
- Institute of Specific Prophylaxis and Tropical Medicine, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna
- Judith H. Aberle
- Center for Virology, Medical University of Vienna
- Daniel Aletaha
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Leonhard X. Heinz
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- Michael Bonelli
- Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-022-33036-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
Optimizing COVID-19 vaccination strategies for patients under immunosuppressive medication is of high importance. In this clinical trial including non-seroconverted immunosuppressed patients, a homologous mRNA booster vaccination resulted in higher seroconversion rate than a switch to a vector-based vaccine.
