Hypothalamic remodeling of thyroid hormone signaling during hibernation in the arctic ground squirrel

Helen E. Chmura; Cassandra Duncan; Ben Saer; Jeanette T. Moore; Brian M. Barnes; C. Loren Buck; Helen C. Christian; Andrew S. I. Loudon; Cory T. Williams

doi:10.1038/s42003-022-03431-8

Communications Biology (May 2022)

Hypothalamic remodeling of thyroid hormone signaling during hibernation in the arctic ground squirrel

Helen E. Chmura,
Cassandra Duncan,
Ben Saer,
Jeanette T. Moore,
Brian M. Barnes,
C. Loren Buck,
Helen C. Christian,
Andrew S. I. Loudon,
Cory T. Williams

Affiliations

Helen E. Chmura: Institute of Arctic Biology, University of Alaska Fairbanks
Cassandra Duncan: Department of Biology and Wildlife, University of Alaska Fairbanks
Ben Saer: Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester
Jeanette T. Moore: Institute of Arctic Biology, University of Alaska Fairbanks
Brian M. Barnes: Institute of Arctic Biology, University of Alaska Fairbanks
C. Loren Buck: Northern Arizona University, Department of Biological Sciences
Helen C. Christian: Department of Physiology, Anatomy, and Genetics, Le Gros Clark Building, University of Oxford
Andrew S. I. Loudon: Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester
Cory T. Williams: Institute of Arctic Biology, University of Alaska Fairbanks

DOI: https://doi.org/10.1038/s42003-022-03431-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Arctic ground squirrels hibernating in darkness activate the pars tuberalis - hypothalamus thyroid hormone signaling pathway, remodel hypothalamic tanycytes, and activate the reproductive axis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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