Nature Communications (Sep 2016)
The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression
- Yashar S. Niknafs,
- Sumin Han,
- Teng Ma,
- Corey Speers,
- Chao Zhang,
- Kari Wilder-Romans,
- Matthew K. Iyer,
- Sethuramasundaram Pitchiaya,
- Rohit Malik,
- Yasuyuki Hosono,
- John R. Prensner,
- Anton Poliakov,
- Udit Singhal,
- Lanbo Xiao,
- Steven Kregel,
- Ronald F. Siebenaler,
- Shuang G. Zhao,
- Michael Uhl,
- Alexander Gawronski,
- Daniel F. Hayes,
- Lori J. Pierce,
- Xuhong Cao,
- Colin Collins,
- Rolf Backofen,
- Cenk S. Sahinalp,
- James M. Rae,
- Arul M. Chinnaiyan,
- Felix Y. Feng
Affiliations
- Yashar S. Niknafs
- Michigan Center for Translational Pathology, University of Michigan
- Sumin Han
- Department of Radiation Oncology, University of Michigan
- Teng Ma
- Department of Radiation Oncology, University of Michigan
- Corey Speers
- Department of Radiation Oncology, University of Michigan
- Chao Zhang
- Department of Radiation Oncology, University of Michigan
- Kari Wilder-Romans
- Department of Radiation Oncology, University of Michigan
- Matthew K. Iyer
- Michigan Center for Translational Pathology, University of Michigan
- Sethuramasundaram Pitchiaya
- Michigan Center for Translational Pathology, University of Michigan
- Rohit Malik
- Michigan Center for Translational Pathology, University of Michigan
- Yasuyuki Hosono
- Michigan Center for Translational Pathology, University of Michigan
- John R. Prensner
- Michigan Center for Translational Pathology, University of Michigan
- Anton Poliakov
- Michigan Center for Translational Pathology, University of Michigan
- Udit Singhal
- Michigan Center for Translational Pathology, University of Michigan
- Lanbo Xiao
- Michigan Center for Translational Pathology, University of Michigan
- Steven Kregel
- Michigan Center for Translational Pathology, University of Michigan
- Ronald F. Siebenaler
- Michigan Center for Translational Pathology, University of Michigan
- Shuang G. Zhao
- Department of Radiation Oncology, University of Michigan
- Michael Uhl
- Department of Computer Science and Centre for Biological Signaling Studies (BIOSS), University of Freiburg
- Alexander Gawronski
- School of Computing Science, Simon Fraser University
- Daniel F. Hayes
- Breast Oncology Program, University of Michigan
- Lori J. Pierce
- Department of Radiation Oncology, University of Michigan
- Xuhong Cao
- Michigan Center for Translational Pathology, University of Michigan
- Colin Collins
- Vancouver Prostate Centre
- Rolf Backofen
- Department of Computer Science and Centre for Biological Signaling Studies (BIOSS), University of Freiburg
- Cenk S. Sahinalp
- School of Computing Science, Simon Fraser University
- James M. Rae
- Breast Oncology Program, University of Michigan
- Arul M. Chinnaiyan
- Michigan Center for Translational Pathology, University of Michigan
- Felix Y. Feng
- Michigan Center for Translational Pathology, University of Michigan
- DOI
- https://doi.org/10.1038/ncomms12791
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
LncRNAs have been associated with cancer. Here, the authors carry out a systematic review of lncRNAs in breast cancer and show that DSCAM-AS1is highly expressed in oestrogen receptor positive tumours and enhances cancer through an interaction with hnRNPL; and is also associated with tamoxifen resistance.
