Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Mar 2022)

Time‐Dependent Impact of Sex on the Long‐Term Outcomes After Left Main Revascularization

  • Yong‐Hoon Yoon,
  • Jung‐Min Ahn,
  • Jung Bok Lee,
  • Do‐Yoon Kang,
  • Hanbit Park,
  • Yeong Jin Jeong,
  • Junghoon Lee,
  • Ju Hyeon Kim,
  • Yujin Yang,
  • Junho Hyun,
  • Pil Hyung Lee,
  • Duk‐Woo Park,
  • Seung‐Jung Park

DOI
https://doi.org/10.1161/JAHA.121.021720
Journal volume & issue
Vol. 11, no. 5

Abstract

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Background There are still limited data about the differential effect of sex on long‐term outcomes after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) for left main coronary artery disease. This extended follow‐up study of the MAIN‐COMPARE (Ten‐Year Outcomes of Stents Versus Coronary‐Artery Bypass Grafting for Left Main Coronary Artery Disease) registry evaluated clinical outcomes beyond 10 years. Methods and Results Of 2240 patients with unprotected left main coronary artery disease (PCI=1102 and CABG=1138), all‐cause mortality, the composite of death, Q‐wave myocardial infarction, or stroke, and target vessel revascularization were separately evaluated in both sexes. Of 2240 patients, 631 (28.2%) were women and 1609 (71.8%) were men. Women had lower 10‐year incidences of death and serious composite outcomes than men. The adjusted 10‐year risks of adverse outcomes were similar in men. However, the adjusted 10‐year risks were different according to a prespecified period in women. In the short‐term (0–1 year) period, PCI had a significantly lower risk for serious composite outcomes (adjusted hazard ratio [HR], 0.41; 95% CI, 0.19–0.91; P=0.03) compared with CABG. The adjusted risks for death and serious composite outcomes were significantly higher after PCI than after CABG, during the midterm (1–5 years) period (death; adjusted HR, 3.99; 95% CI, 2.01–7.92; P<0.001 and composite outcome; adjusted HR, 2.93; 95% CI, 1.59–5.39; P=0.001). Beyond 5 years, adjusted risks were similar after PCI and CABG in women. Conclusions In this 10‐year extended follow‐up study of patients undergoing left main coronary artery revascularization, we observed a time‐dependent impact of sex on the long‐term outcomes after PCI and CABG, especially in women, with significant interactions. However, these results warrant confirmation on larger series of studies. Registration URl: https://www.clinicaltrials.gov; Unique identifier: NCT02791412.

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