Nature Communications (Nov 2022)

Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy

  • Raquel Gómez-Oca,
  • Evelina Edelweiss,
  • Sarah Djeddi,
  • Mathias Gerbier,
  • Xènia Massana-Muñoz,
  • Mustapha Oulad-Abdelghani,
  • Corinne Crucifix,
  • Coralie Spiegelhalter,
  • Nadia Messaddeq,
  • Pierre Poussin-Courmontagne,
  • Pascale Koebel,
  • Belinda S. Cowling,
  • Jocelyn Laporte

DOI
https://doi.org/10.1038/s41467-022-34490-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

Read online

Dynamin 2 is a large GTPase linked to several human diseases. Here, Gómez-Oca et al. investigate the functions of muscle dynamin 2 isoforms and provide insights into their differential implication in centronuclear myopathy pathogenesis and treatment.