Harnessing Nuclear Energy to Gold Nanoparticles for the Concurrent Chemoradiotherapy of Glioblastoma

Jui-Ping Li; Yu-Cheng Kuo; Wei-Neng Liao; Ya-Ting Yang; Sih-Yu Chen; Yu-Ting Chien; Kuo-Hung Wu; Mei-Ya Wang; Fong-In Chou; Mo-Hsiung Yang; Dueng-Yuan Hueng; Chung-Shi Yang; Jen-Kun Chen

doi:10.3390/nano13212821

Nanomaterials (Oct 2023)

Harnessing Nuclear Energy to Gold Nanoparticles for the Concurrent Chemoradiotherapy of Glioblastoma

Jui-Ping Li,
Yu-Cheng Kuo,
Wei-Neng Liao,
Ya-Ting Yang,
Sih-Yu Chen,
Yu-Ting Chien,
Kuo-Hung Wu,
Mei-Ya Wang,
Fong-In Chou,
Mo-Hsiung Yang,
Dueng-Yuan Hueng,
Chung-Shi Yang,
Jen-Kun Chen

Affiliations

Jui-Ping Li: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan
Yu-Cheng Kuo: Department of Radiation Oncology, China Medical University Hospital, Taichung 40447, Taiwan
Wei-Neng Liao: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan
Ya-Ting Yang: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan
Sih-Yu Chen: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan
Yu-Ting Chien: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan
Kuo-Hung Wu: Nuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan
Mei-Ya Wang: Nuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan
Fong-In Chou: Nuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan
Mo-Hsiung Yang: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan
Dueng-Yuan Hueng: School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan
Chung-Shi Yang: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan
Jen-Kun Chen: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan

DOI: https://doi.org/10.3390/nano13212821
Journal volume & issue: Vol. 13, no. 21
p. 2821

Abstract

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Nuclear fission reactions can release massive amounts of energy accompanied by neutrons and γ photons, which create a mixed radiation field and enable a series of reactions in nuclear reactors. This study demonstrates a one-pot/one-step approach to synthesizing radioactive gold nanoparticles (RGNP) without using radioactive precursors and reducing agents. Trivalent gold ions are reduced into gold nanoparticles (8.6–146 nm), and a particular portion of 197Au atoms is simultaneously converted to 198Au atoms, rendering the nanoparticles radioactive. We suggest that harnessing nuclear energy to gold nanoparticles is feasible in the interests of advancing nanotechnology for cancer therapy. A combination of RGNP applied through convection-enhanced delivery (CED) and temozolomide (TMZ) through oral administration demonstrates the synergistic effect in treating glioblastoma-bearing mice. The mean survival for RGNP/TMZ treatment was 68.9 ± 9.7 days compared to that for standalone RGNP (38.4 ± 2.2 days) or TMZ (42.8 ± 2.5 days) therapies. Based on the verification of bioluminescence images, positron emission tomography, and immunohistochemistry inspection, the combination treatment can inhibit the proliferation of glioblastoma, highlighting the niche of concurrent chemoradiotherapy (CCRT) attributed to RGNP and TMZ.

Published in Nanomaterials

ISSN: 2079-4991 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/nanomaterials

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