Nature Communications (Jan 2020)
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy
- Oisín Huhn,
- Martin A. Ivarsson,
- Lucy Gardner,
- Mike Hollinshead,
- Jane C Stinchcombe,
- Puran Chen,
- Norman Shreeve,
- Olympe Chazara,
- Lydia E. Farrell,
- Jakob Theorell,
- Hormas Ghadially,
- Peter Parham,
- Gillian Griffiths,
- Amir Horowitz,
- Ashley Moffett,
- Andrew M. Sharkey,
- Francesco Colucci
Affiliations
- Oisín Huhn
- Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre
- Martin A. Ivarsson
- Department of Pathology, University of Cambridge
- Lucy Gardner
- Department of Pathology, University of Cambridge
- Mike Hollinshead
- Department of Pathology, University of Cambridge
- Jane C Stinchcombe
- Cambridge Institute of Medical Research, University of Cambridge
- Puran Chen
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital
- Norman Shreeve
- Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre
- Olympe Chazara
- Centre for Trophoblast Research, University of Cambridge
- Lydia E. Farrell
- Centre for Trophoblast Research, University of Cambridge
- Jakob Theorell
- Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford
- Hormas Ghadially
- AstraZeneca, Oncology R&D
- Peter Parham
- Department of Structural Biology, Stanford University School of Medicine
- Gillian Griffiths
- Cambridge Institute of Medical Research, University of Cambridge
- Amir Horowitz
- Precision Immunology Institute, Tisch Cancer Institute Icahn School of Medicine at Mount Sinai
- Ashley Moffett
- Centre for Trophoblast Research, University of Cambridge
- Andrew M. Sharkey
- Centre for Trophoblast Research, University of Cambridge
- Francesco Colucci
- Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre
- DOI
- https://doi.org/10.1038/s41467-019-14123-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual innate lymphoid cells (ILCs), identifying subsets with features distinct from blood ILC.
