Ferroptosis: friend or foe in cancer immunotherapy?

Abstract

ABSTRACTFerroptosis has gained interest due to it immunogenicity and the higher sensitivity of cancer cells to it. However, it was recently shown that ferroptosis in tumor-associated neutrophils leads to immunosuppression and negatively impacts therapy. Here, we discuss the potential implications of the two sides (friend versus foe) of ferroptosis in cancer immunotherapy.

Keywords

• Immunogenic cell death
• immunogenic ferroptosis
• cancer immunosuppression