Thoracic Cancer (Jun 2020)

First‐line immune checkpoint therapy in metastatic squamous cell lung cancer harboring both EGFR mutation and high expression of PD‐L1: A case report

  • Kosuke Hamai,
  • Hiroki Tanahashi,
  • Sayaka Ueno,
  • Hanae Konishi,
  • Mirai Matsumura,
  • Akio Nomura,
  • Kanako Nakamoto,
  • Shoko Isoyama,
  • Takuya Tanimoto,
  • Hiroyasu Shoda,
  • Nobuhisa Ishikawa

DOI
https://doi.org/10.1111/1759-7714.13436
Journal volume & issue
Vol. 11, no. 6
pp. 1716 – 1719

Abstract

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A 90‐year‐old female was admitted to our hospital with a history of a dry cough. Chest computed tomography (CT) scan showed a tumor shadow, and CT‐guided lung biopsy revealed squamous cell carcinoma harboring an EGFR mutation. In addition, programmed death‐ligand 1 (PD‐L1) was highly expressed with a tumor proportion score (TPS) of >75%. Pembrolizumab therapy in the first‐line setting was not effective, and the patient died at six months from the first visit. Squamous cell lung cancers (SCLCs) with both EGFR mutation and high expression of PD‐L1 are very rare.

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