Nature Communications (Nov 2016)
Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
- Maria Pelliccia,
- Patrizia Andreozzi,
- Jayson Paulose,
- Marco D’Alicarnasso,
- Valeria Cagno,
- Manuela Donalisio,
- Andrea Civra,
- Rebecca M. Broeckel,
- Nicole Haese,
- Paulo Jacob Silva,
- Randy P. Carney,
- Varpu Marjomäki,
- Daniel N. Streblow,
- David Lembo,
- Francesco Stellacci,
- Vincenzo Vitelli,
- Silke Krol
Affiliations
- Maria Pelliccia
- European School of Molecular Medicine (SEMM), IFOM-IEO-Campus, via Adamello 16, Milan 20139, Italy
- Patrizia Andreozzi
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- Jayson Paulose
- Instituut-Lorentz for theoretical physics, Leiden University
- Marco D’Alicarnasso
- European School of Molecular Medicine (SEMM), IFOM-IEO-Campus, via Adamello 16, Milan 20139, Italy
- Valeria Cagno
- Department of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga Hospital
- Manuela Donalisio
- Department of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga Hospital
- Andrea Civra
- Department of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga Hospital
- Rebecca M. Broeckel
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Nicole Haese
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- Paulo Jacob Silva
- Institute of Materials and Interfaculty Bioengineering Institute, École polytechnique fédérale de Lausanne
- Randy P. Carney
- Institute of Materials and Interfaculty Bioengineering Institute, École polytechnique fédérale de Lausanne
- Varpu Marjomäki
- Department of Biological and Environmental Science/Nanoscience Center, University of Jyväskyla
- Daniel N. Streblow
- Vaccine & Gene Therapy Institute, Oregon Health & Science University
- David Lembo
- Department of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, S. Luigi Gonzaga Hospital
- Francesco Stellacci
- Institute of Materials and Interfaculty Bioengineering Institute, École polytechnique fédérale de Lausanne
- Vincenzo Vitelli
- Instituut-Lorentz for theoretical physics, Leiden University
- Silke Krol
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- DOI
- https://doi.org/10.1038/ncomms13520
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 7
Abstract
Keeping viral vaccines cold from the manufacturers to patients is problematic and costly. Here, Krol and others show additives that can significantly improve at very low concentrations the storage of adenovirus type 5 at ambient and elevated temperature.
