Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG

Nikolaos Giannareas; Qin Zhang; Xiayun Yang; Rong Na; Yijun Tian; Yuehong Yang; Xiaohao Ruan; Da Huang; Xiaoqun Yang; Chaofu Wang; Peng Zhang; Aki Manninen; Liang Wang; Gong-Hong Wei

doi:10.1038/s41467-022-34994-z

Nature Communications (Nov 2022)

Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG

Nikolaos Giannareas,
Qin Zhang,
Xiayun Yang,
Rong Na,
Yijun Tian,
Yuehong Yang,
Xiaohao Ruan,
Da Huang,
Xiaoqun Yang,
Chaofu Wang,
Peng Zhang,
Aki Manninen,
Liang Wang,
Gong-Hong Wei

Affiliations

Nikolaos Giannareas: Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu
Qin Zhang: Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu
Xiayun Yang: Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu
Rong Na: Division of Urology, Department of Surgery, Li Ka Shing Faculty of Medicine, the University of Hong Kong
Yijun Tian: Department of Tumour Biology, H. Lee Moffitt Cancer Center and Research Institute
Yuehong Yang: Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu
Xiaohao Ruan: Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Da Huang: Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Xiaoqun Yang: Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Chaofu Wang: Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Peng Zhang: Fudan University Shanghai Cancer Center & MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Shanghai Medical College of Fudan University
Aki Manninen: Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu
Liang Wang: Department of Tumour Biology, H. Lee Moffitt Cancer Center and Research Institute
Gong-Hong Wei: Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu

DOI: https://doi.org/10.1038/s41467-022-34994-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 22

Abstract

Read online

The role of risk loci identified from genome-wide association studies in prostate cancer (PCa) progression remains poorly characterised. Here, the authors report enrichment of transcription factor genes within PCa risk-associated regions and germline-somatic interaction between TMPRSS2-ERG fusion and genetic variations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal