<i>N</i>-Propargylation of Indolo-Triterpenoids and Their Application in Mannich Reaction

Abstract

The introduction of the alkynyl moiety to the triterpenic core through a linkage to the indole nitrogen is described. The reaction of N-propargylindoles with N-methylpiperazine using Mannich reaction led to propargylaminoalkynyl-triterpenoids, whose structures were established by NMR spectroscopy.

Keywords

• triterpenoids
• indoles
• <i>N</i>-propargylation
• alkyne
• Mannich reaction