Metal Graphitic Nanocapsules for Theranostics in Harsh Conditions

Yanxia Yang; Shengkai Li; Hongxiu Bu; Xin Xia; Long Chen; Yiting Xu; Zhuo Chen

doi:10.3389/fchem.2022.909110

Frontiers in Chemistry (May 2022)

Metal Graphitic Nanocapsules for Theranostics in Harsh Conditions

Yanxia Yang,
Shengkai Li,
Hongxiu Bu,
Xin Xia,
Long Chen,
Yiting Xu,
Zhuo Chen

Affiliations

Yanxia Yang: Aptamer Engineering Center of Hunan Province, Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio–Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
Shengkai Li: Aptamer Engineering Center of Hunan Province, Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio–Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
Hongxiu Bu: Aptamer Engineering Center of Hunan Province, Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio–Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
Xin Xia: Aptamer Engineering Center of Hunan Province, Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio–Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
Long Chen: Faculty of Science and Technology, University of Macau, Macau, China
Yiting Xu: Key Laboratory of Theoretical Organic Chemistry and Function Molecule, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, China
Zhuo Chen: Aptamer Engineering Center of Hunan Province, Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio–Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China

DOI: https://doi.org/10.3389/fchem.2022.909110
Journal volume & issue: Vol. 10

Abstract

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Metal nanoparticles (NPs) with superior physicochemical properties and biocompatibility have shown great potential in theranostics. However, metal NPs show poor stability in some harsh conditions such as strong acid, oxidation, corrosion and high-temperature conditions, which limits their extensive bioapplications. To address such issue, a variety of superstable metal graphitic nanocapsules with the metal cores confined in the nanospace of few-layer graphitic shell have been developed for biodetection and therapy in harsh conditions. In this mini-review, we summarize the recent advances in metal graphitic nanocapsules for bioapplications in harsh conditions. Firstly, their theranostic performance in non-intrinsic physiological harsh environment, including oxidation, corrosion and high-temperature conditions, is systematically discussed. Then, we highlight their theranostic performance in the harsh stomach condition that is strong acidic and pepsin-rich. It is expected that this review will offer inspiration to facilitate the exploitation of novel theranostic agents that are stable in harsh conditions.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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