Nature Communications (Sep 2017)
Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
- Michelle L. Krishnan,
- Juliette Van Steenwinckel,
- Anne-Laure Schang,
- Jun Yan,
- Johanna Arnadottir,
- Tifenn Le Charpentier,
- Zsolt Csaba,
- Pascal Dournaud,
- Sara Cipriani,
- Constance Auvynet,
- Luigi Titomanlio,
- Julien Pansiot,
- Gareth Ball,
- James P. Boardman,
- Andrew J. Walley,
- Alka Saxena,
- Ghazala Mirza,
- Bobbi Fleiss,
- A. David Edwards,
- Enrico Petretto,
- Pierre Gressens
Affiliations
- Michelle L. Krishnan
- Centre for the Developing Brain, Department of Perinatal Imaging and Health, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital
- Juliette Van Steenwinckel
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Anne-Laure Schang
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Jun Yan
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Johanna Arnadottir
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Tifenn Le Charpentier
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Zsolt Csaba
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Pascal Dournaud
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Sara Cipriani
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Constance Auvynet
- Pierre and Marie Curie University, UMRS-1135, Sorbonne Paris Cité
- Luigi Titomanlio
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Julien Pansiot
- PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité
- Gareth Ball
- Centre for the Developing Brain, Department of Perinatal Imaging and Health, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital
- James P. Boardman
- Medical Research Council/University of Edinburgh Centre for Reproductive Health
- Andrew J. Walley
- Cell Biology and Genetics Research Centre, St. George’s University of London
- Alka Saxena
- Genomics Core Facility, NIHR Biomedical Research Centre, Guy’s and St. Thomas’ NHS Foundation Trust
- Ghazala Mirza
- Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology
- Bobbi Fleiss
- Centre for the Developing Brain, Department of Perinatal Imaging and Health, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital
- A. David Edwards
- Centre for the Developing Brain, Department of Perinatal Imaging and Health, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital
- Enrico Petretto
- Duke-NUS Medical School
- Pierre Gressens
- Centre for the Developing Brain, Department of Perinatal Imaging and Health, Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00422-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role.
