Assessment of Association of rs2200733 SNP on Chromosome 4q25 with the Risk of the Development of Atrial Fibrillation in the Russian Population

Abstract

The aim of our case-control study was to investigate the possible genetic association of the rs2200733 SNP on chromosome 4q25 with AF in the Russian population as this association has not been examined before in this ethnicity. Methods and Results: A total of 76 unrelated individuals diagnosed with AF and 73 control subjects without any cardiovascular pathology were included in this study. The diagnosis of AF was based on ECG and/or Holter ECG data following standard diagnostic criteria. We found that the TT genotype of the rs2200733 SNP was associated with a higher risk of AF (OR=1.4, 95% CI: 1.1-12.4). The homozygote minor rare allele genotype TT of the rs2200733 SNP tended to elevate the risk of lone AF development (OR=2.5, 95% CI: 1.2-19.5). A risk of secondary AF development did not depend on rs2200733 SNP on chromosome 4q25 (OR=0.5, 95% CI: 0.2-1.3). Conclusion: Our results provide additional evidence for the association between the rs2200733 (4q25) SNP on chromosome 4q25 and AF, emphasizing the need for further studies examining the role of this polymorphism in AF.

Keywords

• atrial fibrillation
• single nucleotide polymorphism
• chromosome 4q25
• rs2200733
• odds ratio