A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

Eric M. Chapman; Benjamin Lant; Yota Ohashi; Bin Yu; Michael Schertzberg; Christopher Go; Deepika Dogra; Janne Koskimäki; Romuald Girard; Yan Li; Andrew G. Fraser; Issam A. Awad; Salim Abdelilah-Seyfried; Anne-Claude Gingras; W. Brent Derry

doi:10.1038/s41467-019-09829-z

Nature Communications (Apr 2019)

A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

Eric M. Chapman,
Benjamin Lant,
Yota Ohashi,
Bin Yu,
Michael Schertzberg,
Christopher Go,
Deepika Dogra,
Janne Koskimäki,
Romuald Girard,
Yan Li,
Andrew G. Fraser,
Issam A. Awad,
Salim Abdelilah-Seyfried,
Anne-Claude Gingras,
W. Brent Derry

Affiliations

Eric M. Chapman: Department of Molecular Genetics, University of Toronto
Benjamin Lant: Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children
Yota Ohashi: Department of Molecular Genetics, University of Toronto
Bin Yu: Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children
Michael Schertzberg: The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
Christopher Go: Department of Molecular Genetics, University of Toronto
Deepika Dogra: Institute for Biochemistry and Biology, Potsdam University
Janne Koskimäki: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine
Romuald Girard: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine
Yan Li: University of Chicago Center for Research Informatics, The University of Chicago
Andrew G. Fraser: Department of Molecular Genetics, University of Toronto
Issam A. Awad: Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine
Salim Abdelilah-Seyfried: Institute for Biochemistry and Biology, Potsdam University
Anne-Claude Gingras: Department of Molecular Genetics, University of Toronto
W. Brent Derry: Department of Molecular Genetics, University of Toronto

DOI: https://doi.org/10.1038/s41467-019-09829-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates the pathological defects observed in CCM.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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