The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis

Pengfei Guo; Nam Hoang; Joseph Sanchez; Elaine H. Zhang; Keshari Rajawasam; Kristiana Trinidad; Hong Sun; Hui Zhang

doi:10.1038/s41467-022-34348-9

Nature Communications (Nov 2022)

The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis

Pengfei Guo,
Nam Hoang,
Joseph Sanchez,
Elaine H. Zhang,
Keshari Rajawasam,
Kristiana Trinidad,
Hong Sun,
Hui Zhang

Affiliations

Pengfei Guo: Department of Chemistry and Biochemistry, University of Nevada
Nam Hoang: Department of Chemistry and Biochemistry, University of Nevada
Joseph Sanchez: Department of Chemistry and Biochemistry, University of Nevada
Elaine H. Zhang: College of Natural Resources and College of Letters and Science, University of California
Keshari Rajawasam: Department of Chemistry and Biochemistry, University of Nevada
Kristiana Trinidad: Department of Chemistry and Biochemistry, University of Nevada
Hong Sun: Department of Chemistry and Biochemistry, University of Nevada
Hui Zhang: Department of Chemistry and Biochemistry, University of Nevada

DOI: https://doi.org/10.1038/s41467-022-34348-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here the authors show the assembly/disassembly of mammalian SWI/SNF complexes is dynamically regulated by a lysine methylation mechanism involving the demethylase LSD1 and the methyl-lysine reader L3MBTL3, which recognizes SET7-methylated lysines in SMARCC1 and SMARCC2 to target them for CRL4 ubiquitin ligase-mediated proteolysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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