Nature Communications (Apr 2017)
A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory
- Virginie Freytag,
- Tania Carrillo-Roa,
- Annette Milnik,
- Philipp G. Sämann,
- Vanja Vukojevic,
- David Coynel,
- Philippe Demougin,
- Tobias Egli,
- Leo Gschwind,
- Frank Jessen,
- Eva Loos,
- Wolfgang Maier,
- Steffi G. Riedel-Heller,
- Martin Scherer,
- Christian Vogler,
- Michael Wagner,
- Elisabeth B. Binder,
- Dominique J. -F. de Quervain,
- Andreas Papassotiropoulos
Affiliations
- Virginie Freytag
- Division of Molecular Neuroscience, Department of Psychology, University of Basel
- Tania Carrillo-Roa
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Annette Milnik
- Division of Molecular Neuroscience, Department of Psychology, University of Basel
- Philipp G. Sämann
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Vanja Vukojevic
- Division of Molecular Neuroscience, Department of Psychology, University of Basel
- David Coynel
- Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
- Philippe Demougin
- Division of Molecular Neuroscience, Department of Psychology, University of Basel
- Tobias Egli
- Division of Molecular Neuroscience, Department of Psychology, University of Basel
- Leo Gschwind
- Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
- Frank Jessen
- German Center for Neurodegenerative Diseases (DZNE)
- Eva Loos
- Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
- Wolfgang Maier
- German Center for Neurodegenerative Diseases (DZNE)
- Steffi G. Riedel-Heller
- Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig
- Martin Scherer
- Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf
- Christian Vogler
- Division of Molecular Neuroscience, Department of Psychology, University of Basel
- Michael Wagner
- German Center for Neurodegenerative Diseases (DZNE)
- Elisabeth B. Binder
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry
- Dominique J. -F. de Quervain
- Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
- Andreas Papassotiropoulos
- Division of Molecular Neuroscience, Department of Psychology, University of Basel
- DOI
- https://doi.org/10.1038/ncomms15193
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Cortical thickness has high heritability estimates and is known to be influenced by genetic factors. Here, Freytag and colleagues show that DNA methylation patterns of peripheral blood monocytes are also correlated with cortical thickness and memory performance in human.
