Nature Communications (Dec 2018)

Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection

  • Deshni Jayathilaka,
  • Laksiri Gomes,
  • Chandima Jeewandara,
  • Geethal. S. Bandara Jayarathna,
  • Dhanushka Herath,
  • Pathum Asela Perera,
  • Samitha Fernando,
  • Ananda Wijewickrama,
  • Clare S. Hardman,
  • Graham S. Ogg,
  • Gathsaurie Neelika Malavige

DOI
https://doi.org/10.1038/s41467-018-07667-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

The antibody response during infection with dengue virus is a key component involved in the pathogenesis during secondary infection. Here the authors show antibodies targeting NS1 and the epitopes targeted can be associated with disease severity during human infection.