Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function

• Denise Wolleschak,
• Thomas S. Mack,
• Florian Perner,
• Stephanie Frey,
• Tina M. Schnöder,
• Marie-Christine Wagner,
• Christine Höding,
• Marina C. Pils,
• Andreas Parkner,
• Stefanie Kliche,
• Burkhart Schraven,
• Katrin Hebel,
• Monika Brunner-Weinzierl,
• Satish Ranjan,
• Berend Isermann,
• Daniel B. Lipka,
• Thomas Fischer,
• Florian H. Heidel

Affiliations

Denise Wolleschak

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Thomas S. Mack

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Florian Perner

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Stephanie Frey

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Tina M. Schnöder

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Marie-Christine Wagner

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Christine Höding

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Marina C. Pils

Mousepathology, Animal Experimental Unit, Helmholtz-Center for Infection Research, Braunschweig, Germany

Andreas Parkner

Department of Transfusion Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Stefanie Kliche

Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Burkhart Schraven

Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany;Department of Immune Control, Helmholtz Center for Infection Research, Braunschwei, Germany

Katrin Hebel

Department of Experimental Pediatrics, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Monika Brunner-Weinzierl

Department of Experimental Pediatrics, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Satish Ranjan

Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Berend Isermann

Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Daniel B. Lipka

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany;German Cancer Research Center (DKFZ), Division of Epigenomics and Cancer Risk Factors, Heidelberg, Germany

Thomas Fischer

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany

Florian H. Heidel

Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany