BMC Cardiovascular Disorders (Nov 2019)

Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study

  • Tongtong Yu,
  • Yundi Jiao,
  • Jia Song,
  • Dongxu He,
  • Jiake Wu,
  • Zhijun Sun,
  • Zhaoqing Sun

DOI
https://doi.org/10.1186/s12872-019-1239-4
Journal volume & issue
Vol. 19, no. 1
pp. 1 – 7

Abstract

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Abstract Backgroud To assess the value of D-dimer and its combination with The Global Registry of Acute Coronary Events (GRACE) score in predicting in-hospital mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods In 5923 ACS patients undergoing PCI, the role of D-dimer and the added value of D-dimer to GRACE score for predicting in-hospital mortality were tested. Results After multivariable adjustment, D-dimer could significantly predict in-hospital mortality. Also, it could significantly improve the prognostic performance of GRACE score (C-statistic: z = 2.269, p = 0.023; IDI: 0.016, p = 0.032; NRI: 0.291, p = 0.035). Conclusion In patients with ACS undergoing PCI, D-dimer was an independent predictor of in-hospital death. It could also improve the prognostic performance of GRACE score.

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