Pleura and Peritoneum (Jun 2022)
Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design
- Raoof Mustafa,
- Sullivan Kevin M.,
- Frankel Paul H.,
- Fakih Marwan,
- Synold Timothy W.,
- Lim Dean,
- Woo Yanghee,
- Paz Isaac Benjamin,
- Fong Yuman,
- Thomas Rebecca Meera,
- Chang Sue,
- Eng Melissa,
- Tinsley Raechelle,
- Whelan Richard L.,
- Deperalta Danielle,
- Reymond Marc A.,
- Jones Jeremy,
- Merchea Amit,
- Dellinger Thanh H.
Affiliations
- Raoof Mustafa
- Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA
- Sullivan Kevin M.
- Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA
- Frankel Paul H.
- Department of Computation and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA, USA
- Fakih Marwan
- Department of Medical Oncology and Therapeutics, City of Hope National Medical Center, Duarte, CA, USA
- Synold Timothy W.
- Analytical Pharmacology Core, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
- Lim Dean
- Department of Medical Oncology and Therapeutics, City of Hope National Medical Center, Duarte, CA, USA
- Woo Yanghee
- Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA
- Paz Isaac Benjamin
- Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA
- Fong Yuman
- Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA
- Thomas Rebecca Meera
- Department of Pathology, Northwell Health, New York, NY, USA
- Chang Sue
- Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA
- Eng Melissa
- Office of Clinical Research, City of Hope National Medical Center, Duarte, CA, USA
- Tinsley Raechelle
- Office of Clinical Research, City of Hope National Medical Center, Duarte, CA, USA
- Whelan Richard L.
- Department of Surgery, Northwell Health, Donald and Barbara Zucker School of Medicine, New Hyde Park, NY, USA
- Deperalta Danielle
- Department of Surgery, Northwell Health, Donald and Barbara Zucker School of Medicine, New Hyde Park, NY, USA
- Reymond Marc A.
- Department of Surgery, University of Tuebingen, Tubingen, Germany
- Jones Jeremy
- Department of Oncology (Medical), Mayo Clinic, Jacksonville, FL, USA
- Merchea Amit
- Department of Surgery, Mayo Clinic, Jacksonville, FL, USA
- Dellinger Thanh H.
- Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USA
- DOI
- https://doi.org/10.1515/pp-2022-0116
- Journal volume & issue
-
Vol. 7,
no. 4
pp. 169 – 177
Abstract
Peritoneal metastasis (PM) from appendiceal cancer or colorectal cancer (CRC) has significant morbidity and limited survival. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a minimally invasive approach to treat PM. We aim to conduct a dose-escalation trial of mitomycin C (MMC)-PIPAC combined with systemic chemotherapy (FOLFIRI) in patients with PM from appendiceal cancer or CRC.
Keywords
- appendiceal cancer
- colorectal cancer (crc)
- mitomycin c (mmc)
- peritoneal metastasis (pm)
- phase i study
- pressurized intraperitoneal aerosolized chemotherapy (pipac)
