Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study

Masahiro Kikuchi; Hiroyuki Harada; Ryo Asato; Kiyomi Hamaguchi; Hisanobu Tamaki; Masanobu Mizuta; Ryusuke Hori; Tsuyoshi Kojima; Keigo Honda; Takashi Tsujimura; Yohei Kumabe; Kazuyuki Ichimaru; Yoshiharu Kitani; Koji Ushiro; Morimasa Kitamura; Shogo Shinohara; Koichi Omori

doi:10.3390/medicina57040374

Medicina (Apr 2021)

Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study

Masahiro Kikuchi,
Hiroyuki Harada,
Ryo Asato,
Kiyomi Hamaguchi,
Hisanobu Tamaki,
Masanobu Mizuta,
Ryusuke Hori,
Tsuyoshi Kojima,
Keigo Honda,
Takashi Tsujimura,
Yohei Kumabe,
Kazuyuki Ichimaru,
Yoshiharu Kitani,
Koji Ushiro,
Morimasa Kitamura,
Shogo Shinohara,
Koichi Omori

Affiliations

Masahiro Kikuchi: Department of Otolaryngology—Head & Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Hiroyuki Harada: Department of Otolaryngology—Head & Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka 530-8480, Japan
Ryo Asato: Department of Otolaryngology—Head & Neck Surgery, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan
Kiyomi Hamaguchi: Department of Otolaryngology—Head & Neck Surgery, Kobe City Medical Center General Hospital, Hyogo 650-0047, Japan
Hisanobu Tamaki: Department of Otolaryngology—Head & Neck Surgery, Kurashiki Central Hospital, Okayama 710-8602, Japan
Masanobu Mizuta: Department of Otolaryngology—Head & Neck Surgery, Kurashiki Central Hospital, Okayama 710-8602, Japan
Ryusuke Hori: Department of Otolaryngology, Tenri Hospital, Nara 632-0015, Japan
Tsuyoshi Kojima: Department of Otolaryngology, Tenri Hospital, Nara 632-0015, Japan
Keigo Honda: Department of Otolaryngology, Japanese Red Cross Wakayama Medical Center, Wakayama 640-8558, Japan
Takashi Tsujimura: Department of Otolaryngology, Head and Neck Surgery, Japanese Red Cross Otsu Hospital, Shiga 520-0046, Japan
Yohei Kumabe: Department of Otolaryngology-Head & Neck Surgery, Hyogo Prefectural Amagasaki General Medical Center, Hyogo 660-8550, Japan
Kazuyuki Ichimaru: Department of Otolaryngology—Head & Neck Surgery, Kokura Memorial Hospital, Fukuoka 802-8555, Japan
Yoshiharu Kitani: Department of Otorhinolaryngology—Head & Neck Surgery, Shizuoka General Hospital, Shizuoka 420-8527, Japan
Koji Ushiro: Department of Otorhinolaryngology—Head & Neck Surgery, Shiga General Hospital, Shiga 524-8524, Japan
Morimasa Kitamura: Department of Otolaryngology—Head & Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Shogo Shinohara: Department of Otolaryngology—Head & Neck Surgery, Kobe City Medical Center General Hospital, Hyogo 650-0047, Japan
Koichi Omori: Department of Otolaryngology—Head & Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

DOI: https://doi.org/10.3390/medicina57040374
Journal volume & issue: Vol. 57, no. 4
p. 374

Abstract

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Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analysis. Results: LLN metastasis was noted in 67 patients (7.1%). Habitual alcohol consumption and clinical neck node metastasis were independent risk factors for LLN metastasis. LLN metastasis was an independent prognostic factor for disease-free and overall survival, although LLN dissection did not improve survival outcomes. Conclusion: LLN metastasis is an independent adverse prognostic factor. Further prospective studies are needed to fully assess the extent of LLN dissection required in OSCC patients.

Published in Medicina

ISSN: 1010-660X (Print); 1648-9144 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: https://www.mdpi.com/journal/medicina

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