Nature Communications (Feb 2022)
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
- Francesca D’Addio,
- Anna Maestroni,
- Emma Assi,
- Moufida Ben Nasr,
- Giovanni Amabile,
- Vera Usuelli,
- Cristian Loretelli,
- Federico Bertuzzi,
- Barbara Antonioli,
- Francesco Cardarelli,
- Basset El Essawy,
- Anna Solini,
- Ivan C. Gerling,
- Cristina Bianchi,
- Gabriella Becchi,
- Serena Mazzucchelli,
- Domenico Corradi,
- Gian Paolo Fadini,
- Diego Foschi,
- James F. Markmann,
- Emanuela Orsi,
- Jan Škrha,
- Maria Gabriella Camboni,
- Reza Abdi,
- A. M. James Shapiro,
- Franco Folli,
- Johnny Ludvigsson,
- Stefano Del Prato,
- Gianvincenzo Zuccotti,
- Paolo Fiorina
Affiliations
- Francesca D’Addio
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- Anna Maestroni
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- Emma Assi
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- Moufida Ben Nasr
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- Giovanni Amabile
- Enthera S.r.l.
- Vera Usuelli
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- Cristian Loretelli
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- Federico Bertuzzi
- Diabetology Unit, ASST Grande Ospedale Metropolitano Niguarda
- Barbara Antonioli
- Diabetology Unit, ASST Grande Ospedale Metropolitano Niguarda
- Francesco Cardarelli
- NEST-Scuola Normale Superiore
- Basset El Essawy
- Transplantation Research Center, Nephrology Division, Brigham and Women’s Hospital
- Anna Solini
- Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa
- Ivan C. Gerling
- Department of Medicine, University of Tennessee
- Cristina Bianchi
- Section of Diabetes and Metabolic Disease, Department of Clinical and Experimental Medicine, University of Pisa and Azienda Ospedaliero-Universitaria Pisana
- Gabriella Becchi
- Department of Medicine and Surgery, Unit of Pathology, University of Parma
- Serena Mazzucchelli
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- Domenico Corradi
- Department of Medicine and Surgery, Unit of Pathology, University of Parma
- Gian Paolo Fadini
- Department of Medicine, University of Padua
- Diego Foschi
- General Surgery, DIBIC, L. Sacco Hospital, Università di Milano
- James F. Markmann
- Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School
- Emanuela Orsi
- Diabetes Service, Endocrinology and Metabolic Diseases Unit, IRCCS Cà Granda - Ospedale Maggiore Policlinico Foundation
- Jan Škrha
- 3rd Department of Internal Medicine, Charles University, First Faculty of Medicine
- Maria Gabriella Camboni
- Enthera S.r.l.
- Reza Abdi
- Transplantation Research Center, Nephrology Division, Brigham and Women’s Hospital
- A. M. James Shapiro
- Clinical Islet Transplant Program, Alberta Diabetes Institute, University of Alberta
- Franco Folli
- Endocrinology and Metabolism, Department of Health Science, Università di Milano, ASST Santi Paolo e Carlo
- Johnny Ludvigsson
- Crown Princess Victoria Children´s Hospital and Div of Pediatrics, Dept of Biomedical and Clinical Sciences, Linköping University
- Stefano Del Prato
- Section of Diabetes and Metabolic Disease, Department of Clinical and Experimental Medicine, University of Pisa and Azienda Ospedaliero-Universitaria Pisana
- Gianvincenzo Zuccotti
- Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano and Department of Pediatrics, Buzzi Children’s Hospital
- Paolo Fiorina
- International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano
- DOI
- https://doi.org/10.1038/s41467-022-28360-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes.
