Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review

Abstract

Background: Famous synthetic pharmacophores like Filgotinib, Dapiprazole, and Trazodone have Triazolopyridine as their primary building element. It has become more well-known in medicinal chemistry, to which its broad-spectrum impact may be attributed. Objective: The derivatization of the triazolopyridine molecule has been widely discussed in several scientific articles, focusing on its biological and pharmacological properties. As lead compounds for developing new drugs, many analogues of Triazolopyridine have been found. This article summarizes and discusses the literature surrounding the synthesis and biological evaluation of the triazolopyridine framework. Methods: Relevant keywords were used to identify relevant published literature from all relevant databases, including SciFinder, PubMed, and Google Scholar. Supplementary relevant literature bibliographies were also searched to locate linked reports. Results: Step-by-step explanations of the synthetic approaches to Triazolopyridine-based ring systems were found in the literature. All Triazolopyridine derivative's pharmacological activities were enumerated according to their targets, and a detailed structure–activity link was created. Conclusion: The current review highlights various synthetic techniques for fabricating the triazolopyridine framework and its uses across several medical chemistry fields. The wide range of biological effects of compounds with the triazolopyridine skeleton, including those that are antibacterial, antifungal, anticancer, anti-inflammatory, antitubercular, analgesic, anticancer, and antidepressant, make them crucial in the process of developing new drugs and so on. Despite extensive research, the structure-based drug design technique can create new, effective pharmacophores.

Keywords

• Triazolopyridine
• 1,2,3-triazoles
• Biological activities
• 1,2,4-triazoles
• Synthesis