A novel method for heterocyclic amide–thioamide transformations

Abstract

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields.

Keywords

• heterocyclic amides
• heterocyclic thioamides
• N-cyclohexyl dithiocarbamate cyclohexylammonium salt
• novel thiating agent
• thiation