ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS

Abstract

Abstract. The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis. Production of this cytokine provides clinical features of acute pancreatitis, as well as direct cytotoxic effect upon tumor cells. The article also deals with intensified lipid superoxide generation caused by IL-1. Upon development of inflammatory events, interactions between free radicals and membrane lipids provide synthesis of superoxide compounds that display distinct chemotactic activity towards phagocytes and other immunocompetent cells.

Keywords

• acute pancreatitis
• pathogenesis
• il-1
• peroxidation products