Clinical Study on the Prognosis of Patients with Thymoma with Myasthenia Gravis

Abstract

Background and objective Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors. Methods A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way. Results Thymic tumor tissue type credit has correlation with MG, difference was statistically significant (χ2=24.908, P B3 type (65/239, 27.20%) > B1 (27/132, 20.45%) > AB (43/267, 16.10%) > type A, 10.17% (6/59), Masaoka stage has no correlation with MG (χ2=0.365, P=1.365). Survival analysis showed that the WHO classification, Masaoka stage associated with prognosis (P<0.05), and whether the merger MG (χ2=0.113, P=0.736), postoperative adjuvant radiotherapy (χ2=0.380, P=0.538) has nothing to do with the prognosis, postoperative adjuvant chemotherapy is associated with poor prognosis (χ2=14.417, P<0.001). Whether has nothing to do with the prognosis of the thymus resection (χ2=1.548, P=1.548), whether the whole correlated with the curative effect of thymus excision with MG (χ2=24.695, P<0.001). Conclusion Thymoma patients with MG and extended thymectomy have no correlation with prognosis. Extended thymectomy can improve the effect of MG patients.

Keywords

• Thymoma
• Myasthenia gravis
• Extended thymectomy
• Prognosis