Evaluation of oxidative stress factors and lipid profile in patients suffered from stroke heart disease with coronary artery obstruction

Abstract

Introduction: Cardiovascular disease accounts for the highest number of deaths in most industrialized countries and it is increasing in developing countries. Among cardiovascular diseases, coronary heart disease (CHD) is the deadliest cardiovascular disease. High concentrations of reactive oxygen species can cause membrane lipid peroxidation, and impaired regulation of vascular and cardiac cells. Objectives: The present study is an analytical case-control study that tried to estimate the activity of antioxidant enzymes (superoxide dismutase [SOD], catalase), malondialdehyde (MDA) content, total antioxidant capacity (TAC), triglyceride (TG), LDL-c, in CHD patients. Patients and Methods: Seventy-four subjects (male) older than 30 years old who referred to the hospital for angiography after coronary angiography were divided into case and control groups. Subsequently, 10 cc of blood was taken from the subjects. Catalase and SOD activities in erythrocytes were measured by calorimetry and enzymatic inhibition, respectively. Total HDL-c, LDL-c, TG and total cholesterol levels were measured by Pars Azmoon kit. Results: Regarding the P values, the variables of TG, HDL cholesterol, SOD, MDA, TG/HDL-c and TC/HDL-c are effective. Comparison the mean of MDA in two groups of treatment and control showed a significant difference between mean of MDA between two groups. Significant differences were also observed for TG values for the two groups of control (94.03 ± 31.06 mg/dL) and treatment (80.78±160.01 mg/dL). Conclusion: Antioxidant status of patients with CAD was lower than normal subjects. In addition, disturbance in lipid profile parameters confirmed in CAD patients; while TG increased in those patients.

Keywords

• cardiovascular disease
• coronary heart disease
• oxidative stress
• lipid profile