Nature Communications (Jun 2016)
Prosaposin is a regulator of progranulin levels and oligomerization
- Alexandra M. Nicholson,
- NiCole A. Finch,
- Marcio Almeida,
- Ralph B. Perkerson,
- Marka van Blitterswijk,
- Aleksandra Wojtas,
- Basar Cenik,
- Sergio Rotondo,
- Venette Inskeep,
- Laura Almasy,
- Thomas Dyer,
- Juan Peralta,
- Goo Jun,
- Andrew R. Wood,
- Timothy M. Frayling,
- Christian Fuchsberger,
- Sharon Fowler,
- Tanya M. Teslovich,
- Alisa K. Manning,
- Satish Kumar,
- Joanne Curran,
- Donna Lehman,
- Goncalo Abecasis,
- Ravindranath Duggirala,
- Cyril Pottier,
- Haaris A. Zahir,
- Julia E. Crook,
- Anna Karydas,
- Laura Mitic,
- Ying Sun,
- Dennis W. Dickson,
- Guojun Bu,
- Joachim Herz,
- Gang Yu,
- Bruce L. Miller,
- Shawn Ferguson,
- Ronald C. Petersen,
- Neill Graff-Radford,
- John Blangero,
- Rosa Rademakers
Affiliations
- Alexandra M. Nicholson
- Department of Neuroscience, Mayo Clinic
- NiCole A. Finch
- Department of Neuroscience, Mayo Clinic
- Marcio Almeida
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Ralph B. Perkerson
- Department of Neuroscience, Mayo Clinic
- Marka van Blitterswijk
- Department of Neuroscience, Mayo Clinic
- Aleksandra Wojtas
- Department of Neuroscience, Mayo Clinic
- Basar Cenik
- Department of Neuroscience, Molecular Genetics, and Psychiatry, University of Texas Southwestern Medical Center
- Sergio Rotondo
- Department of Cell Biology and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine
- Venette Inskeep
- Division of Human Genetics, Cincinnati Children’s Hospital Research Foundation
- Laura Almasy
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Thomas Dyer
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Juan Peralta
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Goo Jun
- Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston
- Andrew R. Wood
- Genetics of Complex Traits, St Luke’s Campus, University of Exeter Medical School, University of Exeter
- Timothy M. Frayling
- Genetics of Complex Traits, St Luke’s Campus, University of Exeter Medical School, University of Exeter
- Christian Fuchsberger
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Sharon Fowler
- Department of Medicine, University of Texas Health Science Center
- Tanya M. Teslovich
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Alisa K. Manning
- Center for Human Genetics Research, Massachusetts General Hospital
- Satish Kumar
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Joanne Curran
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Donna Lehman
- Department of Medicine/Cardiology and Cellular & Structural Biology, University of Texas Health Science Center at San Antonio
- Goncalo Abecasis
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Ravindranath Duggirala
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Cyril Pottier
- Department of Neuroscience, Mayo Clinic
- Haaris A. Zahir
- Department of Neuroscience, Mayo Clinic
- Julia E. Crook
- Department of Neuroscience, Mayo Clinic
- Anna Karydas
- Department of Neurology, Memory and Aging Center, University of California
- Laura Mitic
- Department of Neurology, Memory and Aging Center, University of California
- Ying Sun
- Division of Human Genetics, Cincinnati Children’s Hospital Research Foundation
- Dennis W. Dickson
- Department of Neuroscience, Mayo Clinic
- Guojun Bu
- Department of Neuroscience, Mayo Clinic
- Joachim Herz
- Department of Molecular Genetics, Neuroscience, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center
- Gang Yu
- Department of Molecular Genetics, Neuroscience, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center
- Bruce L. Miller
- Department of Neurology, Memory and Aging Center, University of California
- Shawn Ferguson
- Department of Cell Biology and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine
- Ronald C. Petersen
- Department of Neurology, Mayo Clinic
- Neill Graff-Radford
- Department of Neurology, Mayo Clinic
- John Blangero
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Rosa Rademakers
- Department of Neuroscience, Mayo Clinic
- DOI
- https://doi.org/10.1038/ncomms11992
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Increasing progranulin (PGRN) levels is a promising approach for treating frontotemporal dementia and other neurodegenerative diseases. Here Nicholson et al.show that the prosaposin (PSAP) locus is associated with plasma PGRN levels and demonstrate that PSAP can alter PGRN levels and its oligomerization.
