Nature Communications (Jan 2022)
Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens
Abstract
Here, using quantitative screens in human cells, the authors reveal distinct effects of naturally-occurring DNAJ chaperone isoforms on pathological aggregation of the Huntington’s disease-associated HTT-polyQ and the ALS-related mutant FUS.