Relationship between Hypertension and the Declining Renal Function in Korean Adults

Abstract

This study examined the association between hypertension (HTN), estimated glomerular filtration rate (eGFR), and urine microalbumin/creatinine ratio (ACR) in Korean adults. Data for 8,922 adults (3,941 men and 4,981 women) aged ≥20 years from the Sixth Korean National Health and Nutrition Examination Survey VI (2013∼2014) were analyzed. In men, after adjusting for the related variables, the odds ratios (ORs) of HTN [systolic blood pressure (SBP) ≥140 mmHg, diastolic blood pressure (DBP) ≥90 mmHg, or use of HTN medications] were significantly higher in the decreased eGFR group [eGFR ＜60 mL/min/1.73 m2, 1.98 (95% CI, 1.21∼3.24)], elevated ACR group [ACR ≥30 mg/g, 2.03 (95% CI, 1.54∼2.69)], and decreased eGFR plus elevated ACR group [eGFR ＜60 mL/min/1.73 m2 and ACR ≥30 mg/g, 6.03 (95% CI, 2.82∼12.92)] than in the normal group (eGFR ≥60 mL/min/1.73 m2 and ACR ＜30 mg/g). In women, after adjusting for the related variables, the ORs of HTN were significantly higher in the decreased eGFR group (2.29, 95% CI, 1.27∼4.13), elevated ACR group (2.22, 95% CI, 1.68∼2.94), and decreased eGFR plus elevated ACR group (10.77, 95% CI, 3.89∼29.82) than the normal group. In conclusion, HTN was associated with a decreased eGFR and elevated ACR in Korean men and women. In addition, the prevalence of HTN increased greatly when a decreased eGFR and elevated ACR occurred simultaneously.

Keywords

• hypertension
• estimated glomerular filtration rate
• urine microalbumin/creatinine ratio
• chronic kidney disease
• albuminuria