Química Nova (Jan 2009)

Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like In vitro release and permeation of a diclofenac diethylamine from microemulsion gel-like

  • José Alexsandro da Silva,
  • Davi Pereira de Santana,
  • Danilo Galindo César Bedor,
  • Valeria Ferreira da Costa Borba,
  • Ana Amélia Moreira Lira,
  • Eryvaldo Socrates Tabosa do Egito

DOI
https://doi.org/10.1590/S0100-40422009000600005
Journal volume & issue
Vol. 32, no. 6
pp. 1389 – 1393

Abstract

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The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudo-ternary phase-diagram concept. The diclofenac diethylamine (DDA) was incorporated in the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results revealed that the commercial DDA emulgel provided significantly higher Kp of DDA (2.2-fold) as compared to the MEG. Similar data were obtained in the permeation studies in which DDA Kp 4.7-fold higher. Therefore, MEG presents higher potential as a topical delivery system for DDA when compared to the commercial DDA emulgel.

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