Chimica Techno Acta (Dec 2020)

8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

  • Yuri A. Azev,
  • Olga S. Koptyaeva,
  • Oleg S. Eltsov,
  • Anton N. Tsmokalyuk,
  • Tatyana A. Pospelova

DOI
https://doi.org/10.15826/chimtech.2020.7.4.18
Journal volume & issue
Vol. 7, no. 4
pp. 237 – 241

Abstract

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The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained. The structure of the resulting adduct was confirmed by 2D 1H-13C HSQC, 1H-13C HMBC, and 1H-15N HMBC spectra.

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