Kidney & Blood Pressure Research (Jul 2014)

Fitness for Entering a Simple Exercise Program and Mortality: A Study Corollary to the Exercise Introduction to Enhance Performance in Dialysis (Excite) Trial

  • Rossella Baggetta,
  • Davide Bolignano,
  • Claudia Torino,
  • Fabio Manfredini,
  • Filippo Aucella,
  • Antonio Barillà,
  • Yuri Battaglia,
  • Silvio Bertoli,
  • Graziella Bonanno,
  • Pietro Castellino,
  • Daniele Ciurlino,
  • Adamasco Cupisti,
  • Graziella D'Arrigo,
  • Luciano De Paola,
  • Fabrizio Fabrizi,
  • Pasquale Fatuzzo,
  • Giorgio Fuiano,
  • Luigi Lombardi,
  • Gaetano Lucisano,
  • Piergiorgio Messa,
  • Renato Rapanà,
  • Francesco Rapisarda,
  • Stefania Rastelli,
  • Lisa Rocca-Rey,
  • Chiara Summaria,
  • Alessandro Zuccalà,
  • Samar Abd ElHafeez,
  • Giovanni Tripepi,
  • Luigi Catizone,
  • Francesca Mallamaci,
  • Carmine Zoccali

DOI
https://doi.org/10.1159/000355797
Journal volume & issue
Vol. 39, no. 2-3
pp. 197 – 204

Abstract

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Background/Aims: In this corollary analysis of the EXCITE study, we looked at possible differences in baseline risk factors and mortality between subjects excluded from the trial because non-eligible (n=216) or because eligible but refusing to participate (n=116). Methods: Baseline characteristics and mortality data were recorded. Survival and independent predictors of mortality were assessed by Kaplan-Meier and Cox regression analyses. Results: The incidence rate of mortality was higher in non-eligible vs. eligible non-randomized patients (21.0 vs. 10.9 deaths/100 persons-year; PConclusions: Deambulation ability mostly explains the difference in survival rate in non-eligible and eligible non-randomized patients in the EXCITE trial. Extending data analyses and outcome reporting also to subjects not taking part in a trial may be helpful to assess the representability of the study population.

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